观察30例T2DM患者,开放性研究,治疗前后自身对照;进行2周清洗期后给予那格列奈、拜唐苹12周,结果与治疗前相比,FPG和zhDG及HbAlC水平均有显著下降(P<0.01),体重增加,肌酐水平升高,但均未超过正常值,肝功能正常。结论那格列奈、拜唐苹有明确的降低FPG、zhPG及HbA的效果,不良反应少,是一组安全、有效的降糖药物。 30 patients with T2DM were observed open-ended study before and after treatment of their own control; 2 weeks after the washout period were given nateglinide, beitang Ping 12 weeks results compared with before treatment, FPG and zhDG and HbAlC levels were significantly decreased (P <0.01), weight gain, creatinine level increased, but did not exceed the normal value, normal liver function. Conclusion Nateglinide and Bai Tang Ping have clear effects of reducing FPG, zhPG and HbA with less adverse reactions, and are safe and effective hypoglycemic drugs.