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应用亚硒酸钠(Na_2SeO_3)防治克山病(1)和大骨节病(2)效果显著,现已广泛用于临床。但其给药方案和长期反复应用能否产生蓄积毒性应予解决,因此,本文研究了Na_2SeO_3的药物代谢动力学。
The application of sodium selenite (Na_2SeO_3) to prevent and treat Keshan disease (1) and Kaschin-Beck disease (2) is effective and has been widely used in clinical practice. However, the toxicity and toxicity of Na_2SeO_3 should be solved if its dosage regimen and long-term repeated use can be solved. Therefore, the pharmacokinetics of Na_2SeO_3 was studied.