Obvious differences in mineralization characteristics exist between the south and north parts of the east part of the Jiangnan Uplift in north Jiangxi Province and south Anhui Province. The regional metallogeny is discussed, and the ore-forming fluid systems are classified in this article. It is proposed that the fluid ore-forming activities in the Jiangnan Uplift both in north Jiangxi and south Anhui have close relationships with the crustmantle interaction and magmatic-tectonic activities. The types and scales of the mineralization on the both sides of the east Jiangnan Uplift were determined by fluid ore-forming systems and geological backgrounds.