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目的:探讨多排CT灌注成像(CTPI)技术对大鼠超急性期脑梗死的诊断价值。方法:雄性SD大鼠50 只,随机分为对照组10只,实验组40只。实验组按大脑中动脉栓塞(MCAO)后0.5h、1h、2h、3h、6h均分为5个 时点,每个时点8只;对照组也分为5个时点,每个时点2只。2组采用GELightSpeed16排CT机于MCAO后各时 点行灌注扫描,分别计算脑血流量(CBF)图、脑血容量(CBV)图、平均通过时间(MTT)图。在三色的功能图像上画 取双侧对称性兴趣区(ROI),获得病灶侧与对侧脑组织的血流动力学参数值,计算CBF的绝对值和相对值。比较 CBF、CBV、MTT成像结果与TTC染色结果并分析2者间的相关性。结果:对照组各参数图均未见异常灌注区,TTC 染色显示双侧大脑半球对称性红染。实验组各参数图均可见缺血梗死区域。MACO后各时点CBV图中的低灌注 体积与CBF图核心区体积之间差异无统计学意义(P>0.05)。TTC染色梗死体积与CBF核心区、CBV异常灌注区 体积均呈正相关较低(r=0.960,P<0.01;r=0.911,P<0.01);TTC染色梗死体积与MTT异常灌注区体积相关性 较低(r=0.800,P<0.01)。结论:16排CTPI可早期发现梗死病变,能全面显示并可量化梗死和缺血半暗带的部 位、范围和程度,为临床诊断和治疗提供个性化信息。
Objective: To investigate the diagnostic value of multislice CT perfusion imaging (CTPI) in the diagnosis of hyperacute cerebral infarction in rats. Methods: 50 male SD rats were randomly divided into control group (n = 10) and experimental group (n = 40). The experimental group was divided into five time points at 0.5 hour, 1 hour, 2 hours, 3 hours and 6 hours after middle cerebral artery occlusion (MCAO), each time point was 8. The control group was also divided into 5 time points, each time point 2 only. Two groups were performed with GELightSpeed16 CT CT perfusion scanning at each time point after MCAO. CBF, CBV and MTT were calculated. Bilateral symmetry regions of interest (ROI) were drawn on the three-color functional images to obtain the hemodynamic parameters of the lesion and the contralateral brain, and the absolute and relative values of CBF were calculated. CBF, CBV, MTT imaging results and TTC staining results and analysis of the correlation between the two. Results: No abnormal perfusion area was found in the control group. TTC staining showed bilateral hemispheric symmetry red staining. The experimental group of parameters can be seen ischemic infarction area. After MACO, there was no significant difference between the volume of CBF and the volume of CBF core area at each time point (P> 0.05). TTC staining infarction volume and CBF core area, CBV abnormal perfusion area volume were positively correlated lower (r = 0.960, P <0.01; r = 0.911, P <0.01); TTC staining infarct volume and volume of abnormal MTT perfusion area Low (r = 0.800, P <0.01). CONCLUSION: Sixteen rows of CTPI can detect infarction lesions early and can fully display and quantify the location, extent and extent of infarction and ischemic penumbra, and provide personalized information for clinical diagnosis and treatment.