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报道ABC-ELISA法检测82例重症肌无力,50例其它神经系统疾病和50例正常对照组血清中抗突触前膜和抗AchR抗体结果。以P/N比值大于2.5为阳性。结果发现:(1)82例重症肌无力抗AchE抗体阳性53例(64.6％),抗突触前膜抗体阳性55例(67.1％)。(2)两种抗体阳性互呈线性相关(r=0.90,p<0.01);64例两种或1种抗体阳性中,以抗突触前膜抗体占优势者极显著地多于以抗AchR抗体占优势者(p<0.01)。(3)抗突触前膜抗体占优势或仅突触前膜抗体阳性者,病程在5年以下者多于5年以上者(p<0.01)。本结果提示,重症肌无力病人血清中不仅存在抗AchR抗体,而且还存在抗突触前膜抗体,该抗体在重症肌无力的自身免疫发病机制中出现较早,并推测该抗体的出现在重症肌无力发病中可能有更重要的意义。
ABC-ELISA was used to detect 82 patients with myasthenia gravis, 50 patients with other neurological diseases and 50 normal controls serum anti-presynaptic membrane and anti-AchR antibody results. P / N ratio greater than 2.5 was positive. The results showed that: (1) 82 cases of myasthenia gravis anti-AchE antibody positive in 53 cases (64.6%), anti-presynaptic membrane antibody was 55 cases (67.1%). (2) The positive correlation between the two antibodies was linearly correlated (r = 0.90, p <0.01). Among the 64 patients with two or one antibody positive, the predominant anti-presynaptic membrane antibodies were significantly more than those with anti-AchR Antibodies predominate (p <0.01). (3) Anti-presynaptic membrane antibody predominance or only pre-synaptic membrane antibody-positive, duration of less than 5 years more than 5 years (p <0.01). The present results suggest that not only anti-AchR antibodies, but also anti-presynaptic antibodies exist in the sera of patients with myasthenia gravis. This antibody appeared earlier in the pathogenesis of autoimmune myasthenia gravis and presumed that the antibody appeared in critically ill patients Myasthenia gravis may have more important implications.