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肝细胞生长因子(HGF)是在血液中发现的一种能促使肝细胞分裂繁殖的蛋白质。在肝部分切除、急性肝炎和肝中毒损伤时,其血中浓度显著升高,与肝再生相关。体内许多组织都能合成HGF,但肝细胞则不产生。人HGF已被纯化,其cDNA及基因组基因均已被克隆、测序。成熟的人HGF由两条肽链以二硫键连结而成,分子量约77kD,α链含4个Kringle区,β链是一个假丝氨酸蛋白酶,整个结构与血凝和纤溶类因子,特别是与血纤维蛋白溶酶原相似。其受体是c-met基因编码产物。基因工程重组的人HGF已试用于临床治疗。
Hepatocyte growth factor (HGF) is a protein found in the blood that promotes the division of liver cells. In the partial hepatectomy, acute hepatitis and liver injury, the blood concentration was significantly increased, and liver regeneration related. HGF is synthesized in many tissues in the body, but not in liver cells. Human HGF has been purified and its cDNA and genomic genes have been cloned and sequenced. Mature human HGF is composed of two peptide chains linked by disulfide bonds with a molecular weight of about 77 kD. The alpha chain contains four Kringle domains. The beta chain is a pseudoserine protease with the entire structure associated with hemagglutination and fibrinolysis, Similar to plasminogen. Its receptor is the c-met gene encoding product. Genetically engineered recombinant human HGF has been tested for clinical treatment.