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目的:探讨缬沙坦不良反应发生的特点及规律,为临床合理用药提供参考。方法:通过对维普数据库和中国知网进行检索,并查阅原始文献,对2000-2009年国内期刊报道的74例缬沙坦所致不良反应进行统计分析。结果:缬沙坦的不良反应主要有头晕、头痛、刺激性干咳、血管神经性水肿、胃肠道反应、首剂低血压、一过性低血压、关节痛等。结论:临床医师应关注缬沙坦所致的不良反应,以确保临床用药安全、合理、有效。
Objective: To investigate the characteristics and regularity of adverse reactions of valsartan and to provide a reference for clinical rational drug use. Methods: By searching the VIP database and CNKI, and consulting the original documents, 74 cases of adverse reactions caused by valsartan were reported from domestic journals in 2000-2009. Results: The main adverse reactions of valsartan were dizziness, headache, irritating dry cough, angioedema, gastrointestinal reaction, first dose of hypotension, transient hypotension, arthralgia and so on. Conclusion: Clinicians should pay attention to the adverse reactions caused by valsartan to ensure that the clinical medication is safe, reasonable and effective.