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目的:探讨慢性阻塞性肺疾病(COPD)急性加重期(AECOPD)患者血清中TNF-α和CRP水平的变化及其临床意义。方法:比较2010年1月至2011年6月来我院就诊的40例AECOPD患者、40例COPD稳定期患者以及35例健康对照组受试者的血清肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平,并分析AECOPD患者的血清CRP、TNF-α水平与动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO_2)的相关关系。结果:血清TNF-α和CRP在健康对照组、COPD稳定期组和AECOPD组中的水平依次升高;AECOPD患者的血清TNF-α和CRP水平均与PaO_2呈负相关,而与PaCO_2无相关关系。结论:血清TNF-α、CRP水平可作为AECOPD患者监测病情、评价疗效以及疾病转归的有效指标。
Objective: To investigate the changes of serum TNF-α and CRP levels in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and their clinical significance. Methods: The serum level of tumor necrosis factor-α (TNF-α) in 40 AECOPD patients, 40 stable COPD patients and 35 healthy control subjects from January 2010 to June 2011 were compared. C-reactive protein (CRP) levels in patients with AECOPD and the relationship between serum CRP and TNF-α levels and arterial partial pressure of blood (PaCO 2) were analyzed. Results: Serum levels of TNF-α and CRP increased in turn in the healthy control group, stable COPD group and AECOPD group. The serum levels of TNF-α and CRP in AECOPD patients were negatively correlated with PaO_2, but not with PaCO_2 . Conclusion: Serum levels of TNF-α and CRP can be used as effective indicators for monitoring the severity of AECOPD patients and evaluating their efficacy and prognosis.