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目的:评估甲泼尼龙和环磷酰胺联合冲击疗法治疗狼疮脑病的疗效和安全性。方法:将83例狼疮脑病患者分成3组进行治疗,分别为标准肾上腺皮质激素(激素)治疗组、激素或环磷酰胺单冲击治疗组和联合冲击治疗组,并观察其血清学指标变化、疗效及不良反应。结果:3组比较以标准激素治疗组疗效最差。联合冲击治疗组和单冲击治疗组比较,前者的血清学指标较后者明显改善;前者疗效(82%)较后者(53%)有所提高(<0.05)两组的不良反应发生率无明显差异。结论:联合冲击疗法是治疗狼疮脑病的一种较为安全、有效的方法。
Objective: To evaluate the efficacy and safety of methylprednisolone combined with cyclophosphamide in the treatment of lupus encephalopathy. Methods: 83 patients with lupus encephalopathy were divided into three groups for treatment, respectively, the standard adrenocorticotropic hormone (hormone) treatment group, hormones or cyclophosphamide single impact treatment group and the combined impact treatment group, and observed changes in their serological indicators, efficacy And adverse reactions. Results: The three groups compared with standard hormone treatment group the worst effect. Serum indexes of the former were significantly improved compared with those of the latter (P <0.05). The former (82%) was better than the latter (53%) (P <0.05). The incidence of adverse reactions No significant difference. Conclusions: Combined stroke therapy is a safe and effective method for the treatment of lupus encephalopathy.