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目的 了解鲍曼不动杆菌医院感染现状及危险因素 ,并证实院内危重病人监护病房(ICU)是否存在由鲍曼不动杆菌同源性菌株引起的感染。方法 对重庆市 4所医院内由鲍曼不动杆菌引发的院内感染 1 4 0例患者的危险因素进行 1∶1病例对照研究 ;同时将近期内某院ICU分离的鲍曼不动杆菌进行M1 3 PCR扩增分型。结果 研究表明与鲍曼不动杆菌医院感染相关的危险因素依次为病情 (OR =8.691 )、免疫抑制剂 (OR =4.85)、机械通气 (OR =3 .68)、抗生素使用种类 (OR =3 .0 1 4 )。基因分型结果显示从ICU分离的 1 1株鲍曼不动杆菌 ,其中有 5株的基因型完全相同。结论病情、免疫抑制剂、机械通气和抗生素使用种类为鲍曼不动杆菌医院感染危险因素 ;院内ICU存在多重耐药鲍曼不动杆菌的感染 ,应加以控制
Objective To understand the current status and risk factors of Acinetobacter baumannii nosocomial infection and to confirm whether there is an infection caused by Acinetobacter baumannii isolates in intensive care unit (ICU) in the hospital. Methods 1: 1 case-control study was conducted on the risk factors of nosocomial infection caused by Acinetobacter baumannii in 4 hospitals in Chongqing. In addition, Acinetobacter baumannii isolated from ICU in a hospital in recent years was used to carry out M1 3 PCR amplification typing. Results The study showed that the risk factors of nosocomial infection with Acinetobacter baumannii were as follows (OR = 8.691), immunosuppressive agents (OR = 4.85), mechanical ventilation (OR = 3.68) .0 1 4). Genotyping results showed that there were 11 strains of Acinetobacter baumannii isolated from ICU, of which 5 had the same genotype. Conclusions The types of illness, immunosuppressant, mechanical ventilation and antibiotic use are the risk factors of nosocomial infection of Acinetobacter baumannii. The infection of multidrug-resistant Acinetobacter baumannii in the hospital ICU should be controlled