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目的:探讨癫癎患者抑郁情绪及其事件相关电位特征,为癫癎病情判定寻找更多的实验室依据。方法:52例癫癎患者和50例健康对照者分别进行汉密尔顿抑郁量表评定和事件相关电位测定,将结果进行对比分析。结果:癫癎组事件相关电位测定的异常率为73.1%(38/52),事件相关电位中N2,P3波潜伏期较对照组延长,P3波幅降低,差异有统计学意义(P<0.01),汉密尔顿抑郁量表评定中相关因子分和总分值与对照组相比,差异有统计学意义(P<0.01)。事件相关电位成分中P3波潜伏期与汉密尔顿抑郁量表评定中相关因子分呈正相关(P<0.01),而P3波幅与其呈负相关(P<0.01)。结论:癫癎患者抑郁情绪及认知障碍明显,事件相关电位测定可作为癫癎患者认知功能的判定指标。
OBJECTIVE: To investigate the depressive mood and its event-related potential in patients with epilepsy and to find more laboratory evidences for the determination of epilepsy. Methods: Fifty-two patients with epilepsy and 50 healthy controls were assessed for Hamilton Depression Scale and event-related potentials, and the results were compared. Results: The abnormality rate of EPI was 73.1% (38/52) in epilepsy group. The latency of N2 and P3 wave in event - related potentials was longer than that in control group, and the amplitude of P3 was decreased (P <0.01) Compared with the control group, the scores of the relevant factors and the total scores in the Hamilton Depression Rating Scale were significantly different (P <0.01). There was a positive correlation between the latency of P3 wave and the related factor in the assessment of Hamilton Depression Scale (P <0.01), while the amplitude of P3 was negatively correlated with it (P <0.01). Conclusion: Epilepsy patients with depression and cognitive impairment significantly, event-related potential measurement can be used as a cognitive index of patients with epilepsy.