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[目的]探讨妊娠期高血压患者血清脂联素(APN)、空腹胰岛素(FINS)、高敏C反应蛋白(hs-CRP)表达水平,并分析APN与其他指标的相关性.[方法]选取2014年3月至2017年3月本院诊治的妊娠期高血压孕妇128例(观察组),其中轻度子痫前期(轻度组)89例,重度子痫前期(重度组)39例.另选取同期正常妊娠晚期孕妇68例为对照组,检测所有入选孕妇的血清 APN、FINS、hs-CRP 及空腹血糖(FPG),并计算胰岛素抵抗指数(IRI),分析APN与FINS、hs-CRP及IRI的相关性.[结果]与对照组对比,轻度组与重度组患者血清 APN水平显著降低,hs-CRP、FINS水平、IRI升高(F=8.712、12.314、10.698、7.383,P =0.045、0.023、0.039、0.049),与轻度组对比,重度组患者的血清APN水平显著降低,hs-CRP、FINS水平及IRI显著升高(t=6.938、8.756、10.318、5.964,P =0.045、0.029、0.014、0.047);经Pearson相关性分析显示,APN与 FINS、hs-CRP 及 IRI 均呈显著负相关(r =-0.289、-0.472、-0.675,P =0.034、0.029、0.013).[结论]妊娠期高血压患者血清中 APN表达水平降低,且其与 FINS、hs-CRP及IRI呈显著负相关.“,”[Objective]To investigate the levels of serum adiponectin(APN),fasting insulin(FINS)and high sensi-tive C reactive protein(hs-CRP)in patients with pregnancy induced hypertension and to analyze the correlation of APN with FINS,hs-CRP and insulin resistance (IRI).[Methods]A total of 128 pregnant women with hypertension during treatment from March 2014 to March 2017 in our hospital were selected as the observation group,including 89 cases of mild preeclampsia (mild group)and 39 cases of severe preeclampsia(severe group).Another 68 normal pregnant women at the same period were selected as the control group.FINS APN,hs-CRP.and fasting blood glucose(FBG)of all preg-nant women were detected,and the IRI was calculated.The correlation of APN with FINS,hs-CRP and IRI were ana-lyzed.[Results]Compared with the control group,the serum APN level in the mild and severe hypertension groups was significantly lower,and the levels of hs-CRP,FINS,and IRI were higher (F=8.712,12.314,10.698,7.383,P =0.045,0.023,0.039,0.049).Compared to the mild hypertension group,serum APN level in the severe hypertension group was significantly lower,and hs-CRP,FINS levels,and IRI were significantly higher (t=6.938,8.856,10.318, 5.964,P =0.045,0.029,0.014,0.047).Pearson correlation analysis showed that there was a significant negative corre-lation of APN with FINS,hs-CRP and IRI (r=-0.289,-0.472,-0.675,P=0.034,0.029,0.013).[Conclusion]The expression level of APN in serum of hypertensive patients with pregnancy is decreased,and it is significantly nega-tively related with FINS,hs-CRP and IRI.