论文部分内容阅读
为了探讨血浆内皮素（ET）与降钙基因相关肽（CGRP）在肾移植手术前后变化及意义。我们对21例肾移植患者采用放射免疫分析法检测其血浆中ET与CGRP在肾移植手术前后的水平。结果：肾移植前尿毒症患者血浆ET含量显著增高（134．31±29．4ng／L），与对照组比较（44．71±11．84ng／L）差异显著（P＜0．01）。肾移植术后ET水平明显下降（112．06±31．44ng／L），与术前比较有显著性差异（P＜0．05），CGRP在移植后（78．11±41．27ng／L）明显高于移植前（40．77±19．52ng／L），差异显著（P＜0．05）。作者认为ET含量在肾脏病患者血中增高与CGRP含量减少两种因素共同加速了患者肾功能的恶化。随着肾移植术后ET浓度下降与CGRP浓度升高，患者高血压症状得以缓解。提示ET与CGRP在肾移植患者血浆中的变化对于判断预后及排斥反应的发生具有重要意义。
To investigate the changes of plasma endothelin (ET) and calcitonin gene related peptide (CGRP) before and after renal transplantation. We detected the levels of ET and CGRP in plasma before and after renal transplantation by radioimmunoassay in 21 renal transplant recipients. Results: The plasma ET level in patients with uremia before kidney transplantation was significantly higher (134.31 ± 29.4ng / L) than that in the control group (44.71 ± 11.84ng / L) (P <0.01). After ET, the level of ET was significantly decreased (112.06 ± 31.44ng / L) compared with that before operation (P <0.05), and the level of CGRP after transplantation was (78.11 ± 41.27ng / L ) Was significantly higher than before transplantation (40.77 ± 19.52ng / L), the difference was significant (P <0.05). Authors believe that ET content in patients with kidney disease increased blood levels and CGRP decreased two factors together to accelerate the deterioration of renal function in patients. With the decrease of ET and the increase of CGRP after renal transplantation, the symptoms of hypertension were relieved. It is suggested that the changes of ET and CGRP in the plasma of renal allograft patients are of great significance for judging prognosis and rejection.