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目的 探讨慢性乙型肝炎 ( CHB)患者伴发情绪障碍的情况及选择性 5-羟色胺再摄取抑制剂 ( SSRI)对其的治疗作用。方法 对本院 1 4 6例 CHB患者和 1 0 7例一般人群进行症状自评量表 ( SCL-90 )评分 ,并作比较 ;另根据结果将 38例伴有情绪障碍的 CHB患者予抗抑郁药 ,5-羟色胺再摄取抑制剂 ( SSRI)帕罗西丁 (赛乐特 )治疗 ,疗程 8周 ,治疗前后进行量表评分比较。结果 CHB患者中伴情绪障碍的患者人数比例大于一般人群 ( P<0 .0 0 1 ) ;治疗组患者经过 8周的赛乐特治疗后 ,前后评分对比 ,患者的症状明显改善 ( P<0 .0 0 1 )。结论 CHB中有较多患者存在抑郁和焦虑情绪 ,用赛乐特治疗能显著改善其症状
Objective To investigate the treatment of mood disorders associated with chronic hepatitis B (CHB) and the therapeutic effect of selective serotonin reuptake inhibitors (SSRI). Methods A total of 146 CHB patients and 107 normal subjects in our hospital were scored and compared with SCL-90. According to the results, 38 CHB patients with mood disorders were treated with anti-depression Drugs, serotonin reuptake inhibitor (SSRI) Paroxetine (Salbutamol) treatment, treatment of 8 weeks, before and after treatment scale score comparison. Results The proportion of patients with emotional disorder in CHB patients was significantly higher than that in the general population (P <0.01). The patients in the treatment group had significantly improved symptoms (P <0 .0 0 1). Conclusions There are more patients with depression and anxiety in CHB, and Salmeteron treatment can significantly improve their symptoms