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该项目以生物矿化原理为指导,将新型抗肿瘤技术与细胞表面的生物矿化相结合,在肿瘤细胞表面构筑了对光敏感的无机/生物高分子、天然色素/生物高分子复合材料形成的智能矿化层。研究了其对肿瘤细胞形成的定域包围或包裹,分析了这些矿化层在近红外光照下对肿瘤细胞的杀伤作用,同时研究了其生物相容性等。该项目的研究涉及化学、生物、医学、材料等多学科的交叉,对于寻找和开拓生物矿化的新用途以及抗肿瘤的新方法、新途径等具有重要的理论和实践意义。
The project, guided by the principle of biomineralization, combines new antitumor technology with biomineralization on the cell surface to create a light-sensitive inorganic / biopolymer, natural pigment / biopolymer composite on the surface of tumor cells Intelligent mineralization. The localization or encapsulation of tumor cells was studied. The killing effect of these mineralized layers on tumor cells in near infrared light was analyzed. The biocompatibility of these mineralized layers was also studied. The research of this project involves many disciplines of chemistry, biology, medicine and materials, which have important theoretical and practical significance for finding and developing new applications of biomineralization, as well as new methods and new anti-tumor approaches.