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目的观察福辛普利、螺内酯及美托洛尔联合治疗慢性左心室射血分数降低心力衰竭患者的临床效果。方法选取医院收治的心力衰竭患者80例为研究对象,随机分为观察组和对照组,每组40例。对照组采用福辛普利作为治疗期间服用的固定药物,观察组在对照组的服药基础上联合螺内酯及美托洛尔进行治疗。治疗1个月后观察2组患者的总有效率及生命体征指标。结果观察组治疗总有效率为92.50%,高于对照组的72.50%(P<0.05)。治疗后,2组各项生命体征数值均改善,观察组心率、心搏出量、左心室射血分数与对照组比较,差异均有统计学意义(P<0.01)。结论福辛普利、螺内酯及美托洛尔联合治疗慢性左心室射血分数降低心力衰竭患者临床效果显著,可有效提高其治疗总有效率,改善患者生命体征指标,值得在临床上推广应用。
Objective To observe the clinical effect of combination of fosinopril, spironolactone and metoprolol in the treatment of chronic heart failure patients with chronic left ventricular ejection fraction. Methods Totally 80 patients with heart failure treated in our hospital were selected as research object and randomly divided into observation group and control group, 40 cases in each group. In the control group, fosinopril was used as the fixed drug during the treatment, and the observation group was treated with spironolactone and metoprolol on the basis of taking the control group. After 1 month of treatment, the total effective rate and vital signs of 2 groups were observed. Results The total effective rate of the observation group was 92.50%, which was higher than that of the control group (72.50%, P <0.05). After treatment, the vital signs in both groups were improved. The heart rate, stroke volume and left ventricular ejection fraction in the observation group were significantly different from those in the control group (P <0.01). Conclusion Fosinopril, spironolactone and metoprolol combined treatment of chronic left ventricular ejection fraction in patients with heart failure to reduce the clinical effect was significant, which can effectively improve the total effective rate of treatment and improve the vital signs of patients, it is worth in the clinical application.