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雌激素神经效应的分子机制主要是通过ERβ和ERα以二聚体形式与其伴侣分子结合 ,作用于靶基因启动子ERE ,调节基因转录水平。雌激素对大脑神经元的多靶向调节作用包括 :具有突触效应 ,增加大鼠海马神经元棘突密度和神经传导作用 ;促进脑原性神经生长因子 (BDNF)表达 ,使细胞再生和死亡达到平衡状态 ;具有对性发育过程中大脑神经内分泌组织分化的可塑作用 ,促进性分化和成熟 ;对神经元具有保护作用 ,改善认知功能和抑制神经元凋亡。
The molecular mechanism of estrogen nerve effects mainly through ERβ and ERα dimer with its partner molecules, acting on the target gene promoter ERE, regulate gene transcription level. Multi-targeted regulation of estrogen on cerebral neurons includes synaptic effects that increase the spinous process density and neurotransmission in hippocampal neurons of rats; promote the expression of brain-derived nerve growth factor (BDNF) and regenerate and kill cells To achieve equilibrium; with sexual development of neuronal endocrine differentiation of the plastic role, promote differentiation and maturation; have a protective effect on neurons, improve cognitive function and inhibit neuronal apoptosis.