Crystal plasticity theory was used to simulate upsetting tests of different dimensions and grain size micro copper cylinders in this study on the fluctuant flow stress scale effect. Results showed that with the decrease of billet grain quantity, flow stress fluctuation is not always increased, but there is a maximum. Through this study, the fluctuant flow stress scale effect can be understood deeper, and relevant necessary information was obtained for further prediction and control of this scale effect and to design the microforming process and die. Crystal plasticity theory was used to simulate upsetting tests of different dimensions and grain size micro copper cylinders in this study on the fluctuant flow stress scale effect. Results showed that with the decrease of billet grain quantity, flow stress fluctuation not not always increased, but there Through this study, the fluctuant flow stress scale effect can be understood deeper, and relevant necessary information was obtained for further prediction and control of this scale effect and to design the microforming process and die.