目的:通过对比三种促排卵方案用于子宫内膜异位症(EMs)患者体外受精-胚胎移植(IVF-ET)的妊娠及出生结局,探讨不同年龄患者最佳促排卵方案。方法:回顾性分析行IVF-ET助孕治疗的165例EMs患者的203个周期的临床资料。按年龄及促排卵方案进行分组:年龄<35岁,分长方案组(n=51)、超长方案组(n=61)和改良超长方案组(n=24);年龄≥35岁,分长方案组(n=16)、超长方案组(n=33)和改良超长方案组(n=18)。统计各组实验室结果、妊娠结局及出生婴儿各项指标。结果:1年龄<35岁者超长方案组的正常卵裂率(99.3%vs96.0%,P=0.008)、优质胚胎率(75.7%vs 67.1%,P=0.021)、着床率(42.2%vs 27.1%,P=0.022)和临床妊娠率(63.3%vs 37.8%,P=0.011)均高于长方案组;2年龄≥35岁者改良超长方案组的可移植胚胎率(93.5%vs70.4%vs 75.5%,P=0.011)、优质胚胎率(91.9%vs 55.1%vs 65.5%,P<0.001)和胚胎利用率(95.1%vs 72.6%vs 79.4%,P=0.002)均高于长方案组和超长方案组。结论:年龄<35岁EMs患者采用长方案促排卵效果不佳,而采用超长方案促排卵临床结局相对较好;年龄≥35岁EMs患者采用改良超长方案促排卵实验室结果最佳。 OBJECTIVE: To compare the pregnancy and birth outcomes of in vitro fertilization-embryo transfer (IVF-ET) in patients with endometriosis (EMs) by comparing three ovulation induction protocols and explore the optimal ovulation induction schedule in patients of different ages. Methods: The clinical data of 203 cycles of 165 patients with EMs undergoing IVF-ET assisted pregnancy were retrospectively analyzed. The patients were divided into three groups according to age and ovulation induction program: age 35 years, long-term regimen group n = 51, long-term regimen group n = 61 and long-term improvement regimen group n = 24, Long-term program group (n = 16), long-term program group (n = 33), and long-term improvement program group (n = 18). Statistics laboratory results, the outcome of pregnancy and the indicators of the newborn baby. Results: The normal cleavage rate (99.3% vs 96.0%, P = 0.008), high quality embryo rate (75.7% vs 67.1%, P = 0.021), implantation rate % vs 27.1%, P = 0.022) and clinical pregnancy rate (63.3% vs 37.8%, P = 0.011) were higher than those in the long-term treatment group. The rate of transplantable embryos in the long- vs 70.4% vs 75.5%, P = 0.011), high quality embryos (91.9% vs 55.1% vs 65.5%, P <0.001) and embryo utilization rates (95.1% vs 72.6% vs 79.4%, P = 0.002) In the long program group and long program group. Conclusion: Long-term ovulation induction is ineffective in patients with EMs younger than 35 years old, while ovulation induction with long-length regimen is relatively good. The results of ovulation induction test in patients with EMs ≥35 years old using the optimized long-length regimen are the best.