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用免疫酶法分析了糖尿病患者及甲状腺疾病患者血清中的胰岛细胞抗体(ICA)的水平,结果为经胰岛素吸收后,IDDM组阳性率为467%(最高),NIDDM组阳性率为133%,甲状腺疾病组(其中1例Graves’病伴糖尿病ICA阳性)阳性率为4%,健康组为0统计学分析,P<005,具有显著性差异,表明ICA是I型糖尿病的特异性免疫标志物,ICA检测作为对IDDM与NIDDM的鉴别诊断,特别是对LADA糖尿病患者的鉴别诊断具有重要意义,宜在糖尿病临床诊疗中推广应用
The level of ICA in sera of patients with diabetes and thyroid diseases was analyzed by immunoenzymatic method. The results showed that the positive rate of IDA was 467% (highest) and the positive rate of NIDDM was 133% after being absorbed by insulin. The positive rate of thyroid disease group (1 case of Graves’ disease with positive ICA of diabetes) was 4%, and that of healthy group was 0, P <005, with significant difference, indicating that ICA is a specific immune marker of type 1 diabetes mellitus , ICA test as a differential diagnosis of IDDM and NIDDM, especially for the differential diagnosis of LADA diabetic patients is of great significance, should be widely used in the clinical diagnosis and treatment of diabetes