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目的:研究几种常用的促透剂对血竭素体外经皮透过的影响,优化健骨膏的处方。方法:采用Franz扩散池,HPLC测定血竭素的浓度,考察促透剂对血竭素透过离体SD大鼠腹部皮肤的影响。结果:不同促透剂的促透效果依次为:月桂氮(?)酮>丙二醇>松节油>油酸>薄荷醇,月桂氮(?)酮不同浓度的促透效果依次为:2％>1％>0．5％>3％。结论:选择2％氮酮为健骨膏的促透剂时,透皮效果较好。
OBJECTIVE: To study the effects of several commonly used transdermal enhancers on the percutaneous permeation of ddractin in vitro and to optimize the formulation of Jiangu ointment. Methods: The concentration of dradicortin was determined by HPLC with Franz diffusion cell, and the effect of the enhancer on the abdominal skin of isolated SD rats was investigated. RESULTS: The permeation-enhancing effects of different transdermal enhancers were as follows: lauric nitrogen (?) ketone> propylene glycol> turpentine oil> oleic acid> menthol, and the effect of different concentrations of lauric nitrogen (?) ketone was: 2%> 1% >0.5%>3%. Conclusion: The transdermal effect is better when 2% azone is used as a transdermal enhancer.