目的调查孕期三卤甲烷内暴露水平及影响因素,为饮水氯化消毒副产物的暴露评估提供科学依据。方法选择湖北省武汉市某医院2011年7—12月入院分娩的277名孕妇进行问卷调查,采用顶空固相微萃取-气相色谱法测定血液中4种三卤甲烷(三氯甲烷、二氯一溴甲烷、一氯二溴甲烷和三溴甲烷)的浓度,采用广义线性回归模型分析探讨孕期三卤甲烷内暴露水平的影响因素。结果血液中三氯甲烷的检出范围为13.08～480.26 ng/L,中位数为70.17 ng/L,检出率为100%;二氯一溴甲烷的检出范围为未检出～38.24 ng/L,中位数为3.30 ng/L,检出率为86.6%;一氯二溴甲烷的检出范围为未检出～20.92 ng/L,中位数为0.48 ng/L,检出率为27.4%;三溴甲烷的检出范围为未检出～78.76 ng/L,中位数为1.41 ng/L,检出率为43.7%;总三卤甲烷的范围为17.04～491.42 ng/L,中位数为84.86 ng/L;广义线性回归分析结果显示,血液中三氯甲烷含量和总三卤甲烷含量均与年龄呈正相关(β=0.007,P=0.039;β=0.007,P=0.016),均与饮水煮沸呈负相关(β=-0.170,P=0.003;β=-0.135,P=0.004)。结论年龄和饮水煮沸可能影响孕期三卤甲烷内暴露水平。 Objective To investigate the level of exposure to trihalomethanes in pregnancy and its influencing factors, and to provide a scientific basis for the assessment of exposure to chlorinated disinfection by-products in drinking water. Methods A total of 277 pregnant women admitted to hospital from July to December in 2011 in Wuhan City of Hubei Province were surveyed by headspace solid-phase microextraction-gas chromatography for the determination of four trihalomethanes (chloroform, Monomethyl bromide, monobromochloromethane and tribromomethane), the generalized linear regression model was used to analyze the influencing factors of exposure to trihalomethanes in pregnancy. Results The detection range of chloroform was 13.08 ~ 480.26 ng / L, the median was 70.17 ng / L, the detection rate was 100%. The detection range of dichlorobromomethane was ~ 38.24 ng / L, the median was 3.30 ng / L, the detection rate was 86.6%. The detection range of CHCl 2 was undetectable ~ 20.92 ng / L, the median was 0.48 ng / L, the detection rate was 27.4 %; The detection range of tribromomethane was undetectable ~ 78.76 ng / L, the median was 1.41 ng / L, the detection rate was 43.7%; the total trihalomethanes ranged from 17.04 to 491.42 ng / L, the median (84.86 ng / L). The results of generalized linear regression analysis showed that both the contents of trichloromethane and total trihalomethanes in blood were positively correlated with age (β = 0.007, P = 0.039; β = 0.007, P = 0.016) Negatively correlated with boiled water (β = -0.170, P = 0.003; β = -0.135, P = 0.004). Conclusion Age and drinking water boil may affect trihalomethanes exposure during pregnancy.