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这是在美国冷泉港召开的第二次有关疫苗研究新途径的讨论会,会议主要讨论了预防寄生虫和细菌性疾病的疫苗.会议用较多的时间讨论了疟疾疫苗的前景.考虑到疟疾病原学和流行病学情况,提出3种可能的预防措施:(1)攻击发育中期的疟原虫子孢子抗原;(2)攻击无性生殖的红内期疟原虫(裂殖子)抗原,防止由其繁殖而引起的疾病;(3)防止配子与病媒相互作用.由于疟疾免疫力的期特异性,因此研究了在子孢子内和红内期、红外期蛋白中的潜在的免疫原及其变异性.恶性疟原虫克隆基因的表达成功,为分析疟原虫抗原性开辟了一条新途径.与疟疾免疫性有关的表位顺序分析表明,某些抗原含有较短的重复序列,其意义
This is the second colloquium on new approaches to vaccine research in Cold Spring Harbor, USA, where vaccines for the prevention of parasites and bacterial diseases are discussed and the meeting discusses more about the future of malaria vaccine. Etiology and epidemiology, three possible prophylactic measures are proposed: (1) to challenge the mid-development stage of the Plasmodium sporozoite antigen; (2) to attack the red-stage Plasmodium antigen (merozoite) (3) Prevent gametophyte from interacting with vector Due to the period specificity of malaria immunity, the potential immunogens in infra-red proteins in sporozoites and in the red end and their Variability.The success of the expression of Plasmodium falciparum cloned gene opened up a new way to analyze the antigenicity of Plasmodium.According to the epitope sequence analysis of malaria immunity, some antigens contain shorter repeat sequences, and its significance