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近年来,随着对消化系肿瘤研究的不断深入,糖尿病与消化系肿瘤的关系越来越受到学者们的关注。目前国外大量流行病学调查研究表明:糖尿病患者消化系肿瘤(包括结直肠癌、胰腺癌、原发性肝癌等)的发病率明显增加。2型糖尿病诱发消化系统肿瘤的可能机制包括:(1)胰岛素样生长因子1的作用;(2)高胰岛素血症和胰岛素抵抗的作用;(3)宿主免疫功能紊乱;(4)长期高血糖的作用;(5)遗传因素和致癌因素长期作用及微量元素失衡等多方面因素协同作用。
In recent years, with the deepening of research on the digestive system tumors, the relationship between diabetes and digestive system tumors has drawn more and more attention from scholars. At present, a large number of epidemiological studies abroad show that: the incidence of digestive system cancer in patients with diabetes (including colorectal cancer, pancreatic cancer, primary liver cancer, etc.) increased significantly. Possible mechanisms by which type 2 diabetes induces digestive system tumors include: (1) the role of insulin-like growth factor 1; (2) the role of hyperinsulinemia and insulin resistance; (3) host immune dysfunction; (4) long-term hyperglycemia (5) Genetic factors and long-term role of carcinogenic factors and trace elements imbalance and other factors synergistic effect.