病毒性肝炎仍为常见多发的感染性疾病。维生素D是人体必需的一种固醇类衍生物,参与调节钙磷吸收、免疫与抗炎、细胞增殖与分化等重要生命活动。新近发现,病毒性肝炎患者维生素D普遍缺乏,维生素D又具抗病毒作用,凸显出维生素D与病毒性肝炎的正相关性。本文综述维生素D的代谢补偿途径、受体信号通路与病毒性肝炎发生的分子机制,拟构建基于维生素D的病毒性肝炎发生、诊疗新策略和新方法。 Viral hepatitis is still a common infectious disease. Vitamin D is a necessary steroid derivatives of the body, involved in regulating calcium and phosphorus absorption, immune and anti-inflammatory, cell proliferation and differentiation and other important life activities. Recently found that the general lack of vitamin D in patients with viral hepatitis, vitamin D and antiviral effect, highlights the positive correlation between vitamin D and viral hepatitis. This review summarizes the molecular mechanisms of vitamin D metabolic compensation, receptor signaling pathway and viral hepatitis, and proposes a new strategy and method of diagnosis and treatment of vitamin D-based viral hepatitis.