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目的探讨奥曲肽联合生大黄治疗急性胰腺炎(AP)的临床效果。方法选取九江市第一人民医院2013年1月—2015年10月收治的AP患者86例,根据平行对照法分为参照组和试验组,各43例。患者入院后均接受常规治疗,参照组患者给予奥曲肽治疗,试验组患者在参照组基础上给予生大黄治疗。比较两组患者的临床疗效、临床症状(血清淀粉酶水平、腹痛、首次排便排气、恶心呕吐、发热)缓解时间、平均住院时间及不良反应发生情况。结果试验组患者临床治疗有效率高于参照组(P<0.05)。试验组患者血清淀粉酶恢复时间、腹痛缓解时间、首次排便排气时间、恶心呕吐缓解时间、发热缓解时间及平均住院时间低于参照组(P<0.05)。两组患者均未发生严重不良反应。结论在AP临床治疗过程中,对患者行奥曲肽+生大黄治疗,可以快速缓解患者的临床症状,提高患者临床治疗效果,改善患者生存质量。
Objective To investigate the clinical effect of octreotide combined with rhubarb in the treatment of acute pancreatitis (AP). Methods Eighty-six AP patients admitted from January 2013 to October 2015 in Jiujiang First People’s Hospital were divided into reference group and experimental group according to the method of parallel control, with 43 cases in each group. Patients were admitted to the hospital after treatment, the reference group of patients given octreotide treatment, patients in the test group given rhubarb treatment on the basis of the reference group. The clinical efficacy, clinical symptoms (serum amylase level, abdominal pain, first defecation exhaust, nausea and vomiting, fever) remission time, average length of hospital stay and adverse reactions were compared between the two groups. Results The clinical efficacy of trial group was higher than that of the reference group (P <0.05). The serum amylase recovery time, abdominal pain relief time, first defecation exhaust time, nausea and vomiting relief time, fever relief time and average length of hospital stay in trial group were lower than those in reference group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion In the course of clinical treatment of AP, octreotide + rhubarb treatment can relieve the clinical symptoms, improve the clinical effect and improve the quality of life of the patients.