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目的观察在肺结核并咯血的治疗中采用普鲁卡因联合阿替洛尔方案的疗效和安全性。方法 2012年6月至2013年12月肺结核并咯血住院患者46例,随机分为两组,联合组(23例)采用普鲁卡因联合阿替洛尔治疗,单药组(23例)仅用普鲁卡因止血治疗。两组均根据病情给予抗结核及支持等基础治疗。观察两组的止血效果及不良反应。结果联合组总有效率(95.65%)与单药组(91.30%)比较差异无统计学意义(P>0.05)。联合组止血时间(2.57±1.36)d,明显短于单药组的(3.39±1.14)d(t=2.14,P<0.05)。两组均无严重不良事件发生。结论普鲁卡因联合阿替洛尔较单用普鲁卡因治疗能够明显缩短止血时间,安全性良好。
Objective To observe the efficacy and safety of procaine and atenolol in the treatment of pulmonary tuberculosis and hemoptysis. Methods Forty-six patients with pulmonary tuberculosis and hemoptysis admitted to our hospital from June 2012 to December 2013 were randomly divided into two groups. The combination group (23 cases) was treated with procaine and atenolol, and the single drug group (23 cases) Treatment with procaine hemostasis. Both groups were given basic treatment of anti-tuberculosis and support according to the disease. The hemostatic effects and adverse reactions of the two groups were observed. Results The total effective rate (95.65%) in the combined group was not significantly different from that in the single drug group (91.30%) (P> 0.05). The bleeding time in the combination group (2.57 ± 1.36) d was significantly shorter than that in the single drug group (3.39 ± 1.14) d (t = 2.14, P <0.05). No serious adverse events occurred in both groups. Conclusion procaine combined with atenolol than procaine alone can significantly reduce the bleeding time, good safety.