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[目的]观察依托咪酯脂肪乳靶控输注在肝叶切除手术中的麻醉效果和不良反应，并与丙泊酚进行比较。[方法]择期行肝叶切除手术患者40例（ASAI～II），随机分为依托咪酯脂肪乳组（E组）和丙泊酚组（P组），每组20例。E组靶控输注依托咪酯脂肪乳进行麻醉诱导并维持，P组靶控输注丙泊酚，维持脑电波双频指数（BIS）40～60。手术结束前10min停用依托咪酯脂肪乳或丙泊酚。记录两组麻醉前、插管前1 min、插管后1 min、3 min、5 min、切皮时、手术结束时的收缩压（SBP）、舒张压（DBP）、心率（HR）、BIS ，并记录苏醒时间、合并用药情况及不良反应。[结果]与基础值比较，插管前1 min及插管后3 min、5 min ，两组的SBP、DBP均显著降低（ P ＜0．05），插管后3 min、5 min及手术切皮时，P组HR显著下降（ P ＜0．05）。诱导后各时间点的BIS值均随着麻醉的加深呈进行性下降，与诱导前基础值比较差异有显著性（ P ＜0．05），但两组间各时间点比较差异无显著性（P ＞0．05）。P组麻黄素、阿托品的使用率高于E组，不良反应发生率低于E组，但差异无显著性（P ＞0．05）。E组苏醒时间显著长于P组（ P ＜0．05）。[结论]在肝叶切除手术中，依托咪酯脂肪乳较丙泊酚更有利于血流动力学稳定，但苏醒时间延长，术后恶心呕吐的发生率增加。“,”[Objective]To observe the anesthesia effect and adverse reaction of etomidate fat emulsion by target-con-trolled infusion in liver lobectomy ,and compare them with propofol .[Methods]Forty patients undergoing elective lobe re-section surgery(ASAⅠ ~Ⅱ) were randomly divided into etomidate fat emulsion group (group E) and propofol group(group P) with 20 cases in each group .Group E received etomidate fat emulsion by target-controlled infusion for anesthesia in-duction and maintenance ,while group P received propofol by target-controlled infusion .Dual frequency index(BIS) of e-lectroencephalography was maintained 40~60 .Etomidate fat emulsion or propofol was stopped at 10min before the end of surgery .Systolic blood pressure(SBP) ,diastolic blood pressure(DBP) ,heart rate(HR) and BIS of two groups before an-esthesia ,1min before intubation ,1min ,3min and 5 min after intubation and at skin cutting were recorded .The awake time ,drug combination and adverse reactions were recorded .[Results]Compared with baseline values ,SBP and DBP of two groups at 1min before intubation and 3min and 5min after intubation all significantly decreased ( P 0 .05) .The awake time in group E was significantly longer than that in group P ( P<0 .05) .[Conclusion]Compared with propofol ,etomid-ate fat emulsion in liver lobectomy is more helpful for hemodynamic stability ,but prolongs the awake time and increases the incidence of postoperative nausea and vomiting .