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目的 :探讨血清羧化不全骨钙素(ucOC)浓度与冠心病的关系。方法 :对我院2015年6月~2015年11月收治的131例拟诊的冠心病患者行冠状动脉造影,同时测定血清ucOC浓度及其它指标。使用酶联免疫吸附法(ELISA)测定血清ucOC水平。冠心病组和对照组进行比较,了解冠心病组ucOC水平变化。结果 :冠心病组血清ucOC浓度(1.06±0.32ng/mL)显著低于正常冠状动脉组(1.36±0.31ng/mL)。多元Logistic回归分析显示冠心病的发病率与血清ucOC有关。结论 :血清羧化不全骨钙素与冠心病的发病存在密切关系,且低水平ucOC可能是其独立危险因素之一。
Objective: To investigate the relationship between the serum level of serum carboxy-glucosylated osteocalcin (ucOC) and coronary heart disease. Methods: The coronary angiography was performed on 131 cases diagnosed as coronary heart disease from June 2015 to November 2015 in our hospital. Serum ucOC concentration and other indexes were also measured. Serum ucOC levels were determined using enzyme-linked immunosorbent assay (ELISA). Coronary heart disease group and control group were compared to understand coronary heart disease ucOC level changes. Results: The serum concentration of ucOC in coronary heart disease group (1.06 ± 0.32ng / mL) was significantly lower than that in normal coronary artery group (1.36 ± 0.31ng / mL). Multivariate Logistic regression analysis showed that the incidence of coronary heart disease and serum ucOC related. CONCLUSION: Serum carboxylase incomplete osteocalcin is closely related to the pathogenesis of coronary heart disease. Low levels of ucOC may be one of the independent risk factors.