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盐酸α-普鲁丁(Alphaprodine Hydrochloride)为人工合成的镇痛药,又名 Anadol、Nisentil 等,最近上海新亚制药厂已试制成功。此药在构造上为度冷丁 Dol-untin(利多尔 Lydolum)的同型物。据文献介绍,它有强烈、持久的镇痛及解痉挛作用,并有镇静及催眠等功效。其镇痛效能几乎超过度冷丁。此药主要作用于中枢神经系统及平滑肌,对于痛觉中枢有显著的抑制作用。它的特点是效应快,镇痛作用较强且持久,在长期使用后成瘾的副作用比其它镇痛剂为低,且其他副作用小。文献中虽有以上这些记载,但其镇痛功效及副作用究竟为何,目前各家意见还不一致。
Alphaprodine hydrochloride (Alphaprodine Hydrochloride) for the artificial analgesics, also known as Anadol, Nisentil, etc., recently Shanghai Xinya pharmaceutical factory has been successfully trial. The drug is structurally mimetic Dol-untin (Lydolum) isotype. According to the literature, it has a strong, long-lasting analgesic and antispasmodic effect, as well as sedative and hypnotic effects. Its analgesic efficacy is almost more than meperidine. The drug mainly acts on the central nervous system and smooth muscle, for the pain center was significantly inhibited. It is characterized by its rapid onset of action, its strong and long-lasting analgesic effect, its long-term side effects of addiction compared to other analgesics and its low side effects. Although the above records in the literature, but its analgesic efficacy and side effects of what is the current opinions are not the same.