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目的:探讨血管内皮生长因子C(vascular endothelial growth factor-C,VEGF-C)蛋白在分化型甲状腺癌组织中的表达及与临床病理特征的关系及意义。方法:应用免疫组化SP法检测50例甲状腺乳头状癌(papillary thyroid cancer,PTC)、50例甲状腺滤泡状癌(follicular thyroid cancer,FTC)和20例正常甲状腺(NT)组织VEGF-C蛋白的表达。结果:VEGF-C在PTC、FTC、NT组织的表达不一,阳性率分别为48.0%、24.0%、10.0%(P<0.05);PTC组织的VEGF-C阳性率在淋巴结转移组为85.7%,高于无转移组的40.0%及骨或肺转移组的50.0%(P<0.05);FTC组织的VEGF-C阳性率在淋巴结转移组为57.1%,高于无转移组的17.1%及骨或肺转移组的25.0%(P<0.05);PTC与FTC组织的VEGF-C表达差异主要存在于无转移及骨或肺转移组(P<0.05)。结论:VEGF-C与分化型甲状腺癌的淋巴结转移密切相关,在分化型甲状腺癌的淋巴道转移中起着重要的作用。PTC组织VEGF-C表达明显高于FTC组织,可以解释两者不同的淋巴结侵犯倾向。分化型甲状腺癌组织VEGF-C高表达可能可以预测其淋巴结转移。
Objective: To investigate the expression of vascular endothelial growth factor-C (VEGF-C) in differentiated thyroid carcinoma and its clinical significance. Methods: Fifty cases of papillary thyroid cancer (PTC), 50 cases of follicular thyroid cancer (FTC) and 20 cases of normal thyroid tissue (NT) were detected by immunohistochemical SP method. expression. Results: The positive rates of VEGF-C in PTC, FTC and NT tissues were 48.0%, 24.0% and 10.0% respectively (P <0.05). The positive rate of VEGF-C in PTC tissues was 85.7% , Higher than 40.0% in the non-metastasis group and 50.0% in the bone or lung metastasis group (P <0.05). The positive rate of VEGF-C in FTC was 57.1% in lymph node metastasis group, which was higher than 17.1% Or 25.0% in lung metastasis group (P <0.05). The difference of VEGF-C expression in PTC and FTC tissues mainly existed in non-metastasis and bone or lung metastasis group (P <0.05). Conclusion: VEGF-C is closely related to lymph node metastasis in differentiated thyroid carcinoma and plays an important role in lymphatic metastasis of differentiated thyroid carcinoma. The expression of VEGF-C in PTC tissues was significantly higher than that in FTC tissues, which could explain the different tendency of lymph node invasion. The high expression of VEGF-C in differentiated thyroid cancer may predict its lymph node metastasis.