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目的:探讨舌鳞状细胞癌(squamouscell carcinoma, SCC)中c- erbB -2 表达的临床价值。方法:回顾性分析舌SCC -76 例临床病理资料。对常规HE染色检测证实有肿瘤及瘤旁正常黏膜同时存在的原始蜡块连续切片2张,1 张c erbB 2免疫组织化学染色, 1 张备用。结果:经免疫组织化学检测, c- erbB- 2 阳性者49 例(64 .5%),瘤旁黏膜阳性者15 例( 19. 7%)。c erbB 2基因过度表达与患者生存时间差异有统计学意义,P<0 05;c- erbB -2与舌SCC的转移差异也有统计学意义,P<0 01;c- erbB- 2基因异常表达与舌SCC分期有相关性,P<0 05;c- erbB- 2基因异常表达与舌SCC分级无相关性。c- erbB- 2基因异常表达与舌SCC大小、原发灶的控制、性别、年龄无相关性;c -erbB- 2基因异常表达与局部复发无相关性。结论:在舌SCC中c- erbB- 2基因过度表达可缩短患者的生存时间,并有促进肿瘤细胞转移的可能性。
Objective: To investigate the clinical value of c-erbB-2 expression in squamous cell carcinoma (SCC). Methods: The clinical data of tongue SCC-76 cases were retrospectively analyzed. On the conventional HE staining, there were 2 serial sections of the original paraffin blocks, 1 c erbB 2 immunohistochemical staining and 1 spare. Results: Immunohistochemistry showed that there were 49 cases (64.5%) of c-erbB-2 positive and 15 cases (19.7%) of tumor-adjacent mucosa positive. The difference of c erbB 2 gene overexpression and patient survival time was statistically significant, P <0 05; There were also significant differences in the metastasis of c-erbB -2 and tongue SCC, P <0.01; abnormal expression of c-erbB-2 gene Correlation with tongue SCC staging, P <0.05; Abnormal expression of c-erbB-2 gene had no correlation with tongue SCC classification. The abnormal expression of c-erbB-2 gene had no correlation with the size of SCC, the control of primary tumor, sex and age. There was no correlation between the abnormal expression of c-erbB-2 gene and local recurrence. Conclusion: Overexpression of c-erbB-2 gene in SCC can shorten the survival time of patients and promote the metastasis of tumor cells.