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目的评价非洛地平缓释片联合厄贝沙坦片对男性高血压患者勃起功能的影响。方法选择我院从2012年10月到2013年10月收治的男性高血压患者240例,随机分为两组,每组各120例。对观察组患者采取非洛地平缓释片联合厄贝沙坦片治疗,而对照组患者仅采用非洛地平缓释片治疗。结果两组患者治疗后4周、24周、48周的降压达标率和有效率比较,差异无统计学意义(P>0.05)。治疗后,观察组患者ED患病率明显下降。治疗后48周,观察组轻度ED患病率显著低于对照组,差异有统计学意义(P<0.01)。治疗48周后,观察组患者血清睾酮(T)明显升高,而血清性激素结合球蛋白(SHBG)显著下降,与对照组相比差异具有统计学意义(P<0.01~0.05)。结论非洛地平缓释片联合厄贝沙坦片治疗男性高血压患者可能对患者的性功能影响较小,医疗应用价值显著。
Objective To evaluate the effect of felodipine sustained-release tablets and irbesartan tablets on erectile function in male hypertensive patients. Methods A total of 240 male patients with hypertension who were admitted to our hospital from October 2012 to October 2013 were randomly divided into two groups with 120 cases in each group. Patients in the observation group were treated with felodipine sustained-release tablets and irbesartan tablets, while those in the control group were treated with felodipine sustained-release tablets only. Results There was no significant difference in compliance rate and effective rate between the two groups at 4 weeks, 24 weeks and 48 weeks after treatment (P> 0.05). After treatment, the observation group patients with ED significantly decreased prevalence. At 48 weeks after treatment, the prevalence of mild ED in the observation group was significantly lower than that in the control group (P <0.01). After 48 weeks of treatment, serum testosterone (T) was significantly increased and serum level of sex hormone binding globulin (SHBG) was significantly decreased in the observation group compared with the control group (P <0.01 ~ 0.05). Conclusion Felodipine sustained-release tablets combined with irbesartan tablets in the treatment of male patients with hypertension may have less impact on the sexual function of patients, and the value of medical application is significant.