论文部分内容阅读
为评价35岁以上的孕妇孕中期血清标记物检查筛选先天愚型综合征的敏感性。并对这类孕妇首选非侵入性血清筛选抑或侵入性羊膜腔穿刺的数据资料进行前瞻性研究。1406例年龄35岁以上单胎孕妇行羊膜腔穿刺染色体核型分析的产前检查,在行羊膜腔穿刺前获取血标本,离心并应用特异性孕中期放免试剂盒检查3种血清标记物(甲胎蛋白α-FP、非结合雌三醇、β-绒毛膜促性腺激素)。多胎妊娠、合并糖尿病或在血清学筛选之前已经超声诊断胎儿染色体异常者,不纳入本研究。
Pregnancy screening for pregnant women over the age of 35 to check the sensitivity of the syndrome of Down’s syndrome. And prospective study of such data for pregnant women preferred noninvasive serum screening or invasive amniocentesis. A total of 1406 singleton pregnancies over the age of 35 were examined by amniocentesis for karyotype analysis. Blood samples were collected before amniocentesis and centrifuged. Three kinds of serum markers (A Fetoprotein α-FP, non-conjugated estriol, β-chorionic gonadotropin). Multiple pregnancies, diabetes mellitus, or those who have had an ultrasound diagnosis of fetal chromosomal abnormalities prior to serological screening are not included in this study.