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目的：评价缬沙坦治疗老年患者单纯收缩期高血压（ ISH）的临床疗效及其对患者胰岛素抵抗的影响。方法89例ISH患者口服缬沙坦80 mg· d-1，疗程为8周，治疗期间随访记录患者的血压、空腹胰岛素、胰岛素敏感指数及药物相关不良反应。结果81例患者完成预定研究，8例失访。患者口服缬沙坦1周后收缩压开始明显降低，8周后收缩压明显低于治疗前（ P＜0.05）；治疗结束时，患者空腹胰岛素水平和胰岛素敏感指数明显低于治疗前（ P＜0.05）。随访期间出现眩晕4例，咳嗽2例，不良反应总发生率为6.7％。结论缬沙坦可有效控制老年单纯收缩期高血压，增加胰岛素敏感性，药物不良反应轻微。“,”Objective To evaluate clinical efficacy of valsartan on the blood pressure and insulin sensitivity in aged patients with isolated systol-ic hypertension (ISH).Methods Eight -nine patients with ISH were recruited for the prospect clinical trials .All the patients were given val-sartan 80 mg· d-1 for two month.The blood pressure ( BP) , fasting in-sulin ( FINS ) , insulin sensitive index ( ISI ) and related side effects of this drug were all recorded in the procedure of treatment.Results Eighty-one patients finished the clinical trial.The blood pressure began to decrease after one -week administration and the blood pressure was significantly decreased at the end of the trial compared with the initial condition ( P<0.05 ).The fasting insulin levels and insulin sensitivity indexes were significantly decreased after two -month treatment ( P <0.05 ).Four cases of dizziness and two cases of cough were reported in the procedure of treatment , with an incidence rate of 6.7%.Conclu-sionValsartan can significantly decrease the blood pressure and increase the insulin sensitivity in aged patients with ISH with slight side effects.