目的探讨头颈癌患者外周血PGE2及SIL－2R的临床意义。方法应用放射免疫分析法及双抗体夹心ELISA法分别检测头颈癌患者外周血PGE2及SIL－2R水平。结果头颈癌患者外周血PGE2、SIL－2R水平显著高于头颈部良性疾病患者及正常人（P＞0．05）。30例喉癌患者各期血浆中PGE2含量无差异（P＞0．05），但均显著高于正常人组（P＜0．05）。喉癌患者血清SIL－2R水平除1期与正常人无差异外，其余皆高于正常人组（P＜O．o1），且与临床分期有关。结论头颈癌患者外周血PGE2及SIL－2R水平显著增高，SIL－2R水平与喉癌临床分期密切相关。 Objective To investigate the clinical significance of PGE2 and SIL-2R in peripheral blood of head and neck cancer patients. Methods The levels of PGE2 and SIL-2R in peripheral blood of head and neck cancer patients were detected by radioimmunoassay and double antibody sandwich ELISA. Results The levels of PGE2 and SIL-2R in peripheral blood of head and neck cancer patients were significantly higher than those in benign head and neck patients and normal people (P>0.05). The plasma PGE2 levels in 30 patients with laryngeal carcinoma were not different (P>0.05), but they were all significantly higher than those in normal controls (P<0.05). The levels of serum SIL-2R in patients with laryngeal cancer were all higher than those in the normal group (P