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目的探讨奥美拉唑治疗消化性溃疡并上消化道出血的疗效及安全性。方法选择84例因消化性溃疡并上消化道出血的住院患者,随机分为治疗组和对照组各42例。治疗组采用常规加奥美拉唑治疗,对照组采用常规雷尼替丁治疗,5 d行疗效评定,两组患者空腹胃液pH值变化、疗效比较。结果治疗组总有效率为95.24%高于对照组80.95%,差异有统计学意义(P<0.05);治疗中治疗组pH值升高幅度大于对照组,且未发生任何毒副作用。结论奥美拉唑治疗消化性溃疡病上消化道出血疗效好,无毒副作用,安全可靠,值得临床进一步推广应用。
Objective To investigate the efficacy and safety of omeprazole in the treatment of peptic ulcer and upper gastrointestinal bleeding. Methods Eighty-four inpatients with peptic ulcer and upper gastrointestinal bleeding were randomly divided into treatment group (n = 42) and control group (n = 42). The treatment group was treated with conventional omeprazole, the control group was treated with conventional ranitidine, and the curative effect was evaluated on the 5th day. The changes of fasting gastric juice pH in both groups were compared. Results The total effective rate of the treatment group was 95.24% higher than that of the control group (80.95%), the difference was statistically significant (P <0.05). The pH value of the treatment group was higher than that of the control group, and no toxic or side effects occurred. Conclusion Omeprazole treatment of upper gastrointestinal bleeding peptic ulcer effect, non-toxic side effects, safe and reliable, it is worth further clinical application.