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[目的]通过动物实验应用疏肝解郁中药以方测证,以期揭示肝郁及胃的病理生理基础。[方法]绑带束缚14 d后致大鼠肝郁。观察比较正常组、肝郁组、复健组大鼠胃黏膜病理组织学变化,检测大鼠胃液中游离黏液量、前列腺素E2(PGE2)及胃黏膜组织匀浆液中超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)水平。[结果]肝郁组大鼠胃黏膜出现炎性改变,余2组无显著变化;肝郁组大鼠胃液中游离黏液量、PGE2水平低于其余2组,且胃黏膜组织匀浆液中的SOD、NO水平均低于其余2组,MDA高于其余2组。[结论]疏肝解郁中药可有效预防肝郁及胃病理变化,增强胃黏膜防御保护功能。
[Objective] To apply the traditional Chinese medicine for soothing liver and relieving depression in animal experiments to verify the pathophysiological basis of liver depression and stomach. [Methods] Rats’ liver turbidity was induced 14 days after binding. Observe the histopathological changes of gastric mucosa in the normal group, the liver stagnation group, and the rehabilitation group. Detect the amount of free mucus in the gastric juice, prostaglandin E2 (PGE2) and superoxide dismutase (SOD) in the gastric mucosal tissue homogenate. Malondialdehyde (MDA), nitric oxide (NO) levels. [Results] There were inflammatory changes in the gastric mucosa of rats in the liver-qi group, and there was no significant change in the other two groups. The amount of free mucus and PGE2 levels in the gastric juice of the liver-qi group were lower than those in the other two groups, and the SOD in the gastric mucosa homogenate. The level of NO was lower than that of the other two groups, and MDA was higher than the other two groups. [Conclusion] Shugan Jieyu Chinese medicine can effectively prevent liver stagnation and gastric pathological changes and enhance the protective and protective function of gastric mucosa.