我院中药制剂室因制剂工艺需要,将水蛭粉碎成100目细粉的过程中,导致3人3次出现严重不良反应,现报道如下。1999年3月15日下午,中药制剂室粉碎水蛭,参与操作的3人均为女性,年龄30~34岁。粉碎时间1.5h,操作时均佩带一次性口罩。操作完毕后,有一人很快出现咽喉不适,鼻干,胸闷,咳嗽剧烈,欲吐,咳吐大量白痰,痰中有脏物。4~6h后出现胸闷,咳嗽仍剧烈,痰仍多且有血丝,以至胸痛,寒热往来不断,不能入睡。次日逐渐好转,未经任何治疗。另一操作员4~6h后,感觉面部颈部剧痒,咳嗽,痰多,喉痛,鼻干,至夜发热, Chinese medicine preparation room for our preparation process needs, the leech crushed into 100 mesh powder in the process, resulting in three serious adverse reactions three times are reported below. On the afternoon of March 15, 1999, the Chinese medicine preparation room smashed leeches. All three people involved in the operation were female, aged 30-34 years old. Smash time 1.5h, operation time wearing disposable masks. After the operation, one person soon throat discomfort, dry nose, chest tightness, severe cough, vomiting, coughing a lot of white sputum, sputum dirt. 4 ~ 6h after the chest tightness, cough is still severe, sputum is still more and bloodshot, as well as chest pain, cold and heat constantly, can not sleep. The next day gradually improved, without any treatment. Another operator 4 ~ 6h, itchy facial neck and felt itching, cough, phlegm, sore throat, dry nose, night fever,