血液内补体系统在一些严重的局部或全身病理状态下可发生活化 ,形成大量活化补体片段 ,与血管内皮细胞表面的补体受体结合 ,激活内皮细胞使之结构和功能发生改变 ,并能促进其表达大量活性物质 ,影响血管紧张性、通透性及血液凝固的发生。在创 (烧 )伤、缺血再灌注、器官移植过程中 ,均可见补体系统的活化 ,这些过度活化的补体片段可以导致机体各器官微血管内皮细胞损伤并最终导致其功能障碍 ,从而影响机体的某些病理生理过程。 Blood complement system in some serious local or systemic pathological conditions can occur activation, the formation of a large number of activated complement fragments, and vascular endothelial cell surface complement receptor, activation of endothelial cells so that the structure and function changes, and can promote its Express a large number of active substances, affecting vascular tone, permeability and blood coagulation. In wounds, ischemia-reperfusion and organ transplantation, the activation of the complement system can be seen. These over-activated complement fragments can lead to the damage of microvascular endothelial cells of various organs of the organism and eventually their dysfunction, Some pathophysiological processes.