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目的:分析414例冠心病患者基线C反应蛋白(CRP)水平及对冠状动脉血管重建预后的最佳预测切点。方法:本研究为单中心回顾性研究,入选了北京安贞医院冠心病接受血管重建患者414例,应用ROC曲线分析方法判定CRP最佳切点,比较不同基线C反应蛋白水平患者长期随访的临床结果,中位随访时间为551d。结果:ROC曲线分析CPR5.5mg/L为最佳切点,Cox回归分析,只有CRP对随访主要不良心脑血管事件(MACCE)差异有统计学意义,高CRP组无事件发生率显著少于低CRP组(log-rank,P<0.001)。结论:基线C反应蛋白水平是冠心病血管重建患者预后的独立预测因子,基线CRP5.5mg/L可能是冠心病患者作为判断冠状动脉血管重建后长期预后不良的最佳切点。
OBJECTIVE: To analyze the baseline C-reactive protein (CRP) level in 414 patients with coronary heart disease and to predict the best prognosis for coronary revascularization. Methods: This study was a single-center retrospective study. We selected 414 patients undergoing coronary angioplasty in Beijing Anzhen Hospital for coronary heart disease. ROC curve analysis was used to determine the optimal cut point for CRP. The long-term follow-up of patients with different baseline C-reactive protein levels Results, the median follow-up time was 551d. Results: ROC curve analysis of CPR5.5mg / L was the best cut-point, Cox regression analysis, only CRP was followed up for major adverse cardiovascular events (MACCE) difference was statistically significant, high CRP group was significantly less than the incidence of incident CRP group (log-rank, P <0.001). CONCLUSIONS: Baseline C-reactive protein is an independent predictor of prognosis in patients with coronary revascularization. A baseline CRP of 5.5 mg / L may be the best cut-point for determining long-term prognosis after coronary revascularization in patients with coronary artery disease.