随着人类基因组计划的进展,对于疾病与基因差异表达的关系研究越来越引起研究者的重视,为此人们建立了一系列寻找差异表达基因的方法,本文就这些方法从其原理、在分子生物学中的应用、优缺点及其改进方法等加以简要概述。 With the progress of the human genome project, more and more researchers are paying more attention to the relationship between disease and gene expression. To this end, a series of methods to find differentially expressed genes have been established. In this paper, Biological applications, advantages and disadvantages and its improvement methods to a brief overview.