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本文应用扫描电镜观察了Carboplatin耳中毒引起的内毛细胞表面亚显微结构的改变。发现用药后仅1天,在内毛细胞表面即开始出现球状物,同时伴有个别内毛细胞坏死,注药后3天,大多数内毛细胞的纤毛发生散乱。注药后30天,坏死的内毛细胞处为支持细胞所替代,残存的内毛细胞表面结构可以恢复正常。
In this paper, scanning electron microscopy was used to observe the changes of the surface hair cells sub-microstructure caused by Carboplatin ototoxicity. Found only 1 day after treatment, the surface of the inner hair cells that began to appear globular, accompanied by a few inner hair cells necrosis, 3 days after injection, the majority of hair cells within the cilia scattered. 30 days after injection, necrotic inner hair cells replaced by supporting cells, the residual inner hair cell surface structure can return to normal.