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类肝素酶在细胞表面的表达和分泌对于肿瘤血管的生成和转移的重要作用已越来越受到人们的关注。众所周知,类肝素酶又称内β-葡萄糖苷酸酶,在脉管和神经系统的发育过程中发挥着重要的作用。成年人的类肝素酶可参与人体的创伤修复、组织再造、硫酸乙酰肝素(heparan sulfate,HS)的更新和免疫监视。哺乳动物的类肝素酶蛋白主要定位于核周酸性内吞体、溶酶体颗粒以及中性粒细胞的特殊颗粒,而鸡的类肝素酶则主要定位于细胞膜并即刻被分泌。两者之差异主要源于肽序列信号的不同。研究
The important role of heparanase expression and secretion on the cell surface for the generation and metastasis of tumor blood vessels has drawn more and more attention. It is well known that heparanase, also called beta-glucuronidase, plays an important role in the development of the vascular and nervous system. Heparanase in adults is involved in the repair of wounds in the body, tissue regeneration, heparan sulfate (HS) renewal and immune surveillance. The mammalian heparanase protein mainly locates in the specific nuclei of endocytic nuclei, lysosomes and neutrophils, while the heparanase of chicken mainly locates in the cell membrane and is immediately secreted. The difference between the two is mainly due to the difference of signal of peptide sequence. the study