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目的:探讨皮质-纹状体-脊髓变性病(Creutzfeldt-Jakob disease,CJD)患者脑电图改变的特点。方法 :回顾性分析6例CJD患者的临床病程和脑电图(EEG)资料。结果:6例CJD患者的EEG均呈现阵发性周期性尖慢综合波,且随着病情的进展,其脑电活动进行性减慢,最终发展为持续性、普遍性、双侧对称同步的周期性尖慢综合波放电(PsWC)。结论:CJD患者EEG表现的PsWC多出现于病程中晚期,这种特征性EEG改变是诊断本病的重要依据之一。
Objective: To investigate the characteristics of EEG changes in patients with CJD. Methods: The clinical course and EEG data of 6 patients with CJD were retrospectively analyzed. Results: The EEG of 6 patients with CJD presented paroxysmal cyclical slow and slow synthesis wave. With the progression of the disease, the EEG activity slowed down progressively and eventually developed into a continuous, universal and bilateral symmetrical synchronization Periodic sharp slow synthesis wave discharge (PsWC). Conclusion: The PsWC of EEG in patients with CJD mostly appear in late stage of disease. This characteristic EEG change is one of the important bases for diagnosis of this disease.