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目的:制备美索巴莫片,对影响溶出度的处方因素和工艺因素进行考察。方法:以常用辅料淀粉和砂糖为填充剂,通过正交设计确定了最优处方,并考察了制粒及制片压力等工艺因素的影响。结果:最优处方所制片剂溶出度均符合要求,而工艺因素对片剂的溶出度没有明显的影响。结论:该制剂达到了预期的实验目的,并且成本低,质量优。
OBJECTIVE: To prepare methosartan tablets and investigate the prescription factors and technological factors that affect the dissolution rate. Methods: The optimal prescriptions were determined by orthogonal design using starch and sugar as the excipients. The influence of process factors such as granulation and tabletting pressure were investigated. Results: The dissolution rate of the tablets prepared by the best prescriptions met the requirements, while the process factors had no obvious effect on the dissolution of the tablets. Conclusion: The formulation achieves the intended experimental goal with low cost and excellent quality.