目的:研究益气生津方对正常和运动性疲劳大鼠免疫机能的影响。方法:采用递增时间游泳训练4周、建立Wistar大鼠运动疲劳模型,观察低、中、高3个不同剂量的益气生津方对正常和运动疲劳大鼠CD4、CD8、IL-1、IL-6IgG、IgA和IgM水平、NK细胞活性的影响。结果:益气生津方可显著提高CD4、IgG、IgA和IgM水平、NK细胞活性,并降低运动疲劳所导致的IL-6应激性的升高。结论:益气生津方可以改善大鼠的免疫机能,并对运动疲劳大鼠的免疫应激有保护作用。 Objective: To study the effect of Yiqi Shengjin Recipe on immune function of normal and exercise fatigue rats. METHODS: In order to observe the effects of Yiqi Shengjin Formula on CD4, CD8, IL-1, and IL-3 in normal and exercise-induced fatigue rats, three different doses of low-, middle-, and high-dose Yiqi Shengjin Recipe were established. 6 Effect of IgG, IgA and IgM levels, NK cell activity. Results: Yiqi Shengjin prescription can significantly increase the levels of CD4, IgG, IgA and IgM, NK cell activity, and reduce the increase of IL-6 stress caused by exercise fatigue. Conclusion: Yiqi Shengjin Recipe can improve the immune function of rats, and it has protective effect on immune stress in rats with exercise-induced fatigue.