目的探讨血管内皮生长因子(vascular endothelial cell growth factor,VEGF)、缺氧诱导因子-1α(hypoxia inducible factor-1,HIF-1α)在子宫内膜异位症(endometriosis,EM)的表达及意义。方法采用免疫组织化学S-P法分别检测VEGF、HIF-1α蛋白在EM在位、异位内膜和正常子宫内膜组织中的表达。结果EM组织中VEGF、HIF-1α的表达较正常组内膜明显增高(P<0.01),且HIF-1α与VEGF在EM组织中的表达呈正相关关系。结论VEGF和HIF-1α在EM中过度表达,推测VEGF、HIF-1α与EM的发病密切相关。 Objective To investigate the expression and significance of vascular endothelial cell growth factor (VEGF) and hypoxia inducible factor-1 (HIF-1α) in endometriosis (EM). Methods Immunohistochemical S-P method was used to detect the expression of VEGF and HIF-1α protein in eutopic endometrium, ectopic endometrium and normal endometrium respectively. Results The expression of VEGF and HIF-1α in EM tissue was significantly higher than that in normal group (P <0.01), and the expression of HIF-1α and VEGF in EM tissue was positively correlated. Conclusion VEGF and HIF-1α are overexpressed in EM, suggesting that VEGF and HIF-1α are closely related to the pathogenesis of EM.