随着肿瘤分子生物学的飞速发展，分子靶向治疗已成为肿瘤治疗方法中最具前景的研究领域，分子靶点的研究也早已成为医学界关注的热点。人造血相关的PBX相互作用蛋白质（HPIP）是一种新型的支架蛋白。近年来根据相关文献报道，HPIP与肿瘤生的长、增殖和转移密切相关，有可能成为肿瘤治疗的新靶点。本文总结了HPIP在恶性肿瘤发展中的作用及其相关机制的研究进展。“,”With the rapid development of tumor molecular biology, molecular targeted therapy has become the most promising treatment of cancer and the study of molecular targets has been to be a hot topic for a long time. Remarkably, hematopoietic Pbx?inter?action protein (HPIP), a microtubule?binding protein, is a novel scaffolding protein. To date, according to the relevant literature, HPIP is closely associated with tumor growth, proliferation and metastasis. HPIP may be a new target for cancer therapy in the future. We review a representative set of resent studies and summarizes the progress of mechanisms and significance of HPIP in the develop?ment of malignant tumors.