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伯氨喹对配子体和红细胞外型疟原虫的杀灭作用比扑疟喹强数倍.临床上单用时一般无反应.当伯氨喹的每日剂量用到30毫克或稍高时,易发生疲乏、头昏、恶心、呕吐和腹痛,少数病例出现发绀或药热,停药后迅速恢复.偶可产生急性溶血性贫血的反应,严重者类似黑尿热.乙氨嘧啶具有较佳的病因性预防作用.应用防治剂量(用于预防每周0.025,或半月0.03,抗复发治疗每日0.05,连服二日)时极为安全.如每日应用0.025(系每周的剂量)至一月以上,可致巨细胞性贫血.二药在临床应用中宜持审慎态度,以祈减少乃至防止毒性反应的发生.现将七个单位在进行疟疾休止期抗复发治疗中所发生的反应情况综合如下,以资借监.
Primaquine on the gametophyte and erythrocytic Malaria parasite kill than quinolone times stronger than the number of clinical single-use generally no response when primaquine daily dose of 30 mg or slightly higher, prone to occur Fatigue, dizziness, nausea, vomiting and abdominal pain, a small number of cases of cyanosis or drug fever, rapid recovery after stopping. Even can produce acute hemolytic anemia response, severe cases are similar to black urethra. Sexual prophylaxis. It is extremely safe to use a dosage of prophylaxis (0.025 per week, or 0.03 for half a month, 0.05 per day for anti-relapse treatment, even for 2 days) .For example, daily doses of 0.025 Above, can cause giant cell anemia .Dimension in the clinical application should be cautious, in order to reduce or even prevent the occurrence of toxic reactions.Now the seven units in the anti-relapse malaria treatment during the reaction of the situation As follows, to supervise the capital.